KAMIYA PC-543 說明書

世界*實驗材料供應商 KAMIYA正式授權上海起發為其中國代理， KAMIYA在一直是行業的*,一直為廣大科研客戶提供zui為的產品和服務,上海起發一直秉承為中國科研客戶帶來的產品，的服務，簽約 KAMIYA就是為了給廣大科研客戶帶來更加完善的產品和服務,您的滿意將是我們zui大的收獲

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Kamiya Biomedical Company是一家1983年3月成立的美國生命科學技術公司，總部位于美國加利福尼亞州。本公司致力于為生命科學研究和醫藥機構提供高質量的具有創新性的基礎研究和診斷試劑。

公司的zui早的生命科學研究產品是用于信號轉導研究用蛋白酶抑制劑staurosporine和K252a。1990年，KAMIYA*家在美國推出凋亡研究的重要抗體anti-Fas單克隆抗體。1997年推出了一個完整的臨床診斷和研究用免疫檢測產品線，生產基于免疫投射比濁法(immunoturbidimetric technology)的脂質測定、凝血、炎癥、糖尿病、營養評估及血脂蛋白測定試劑及試劑盒。公司研發的K-ASSAY試劑無需攪拌、溶解和稀釋樣本等繁雜程序。

如今，KAMIYA供應的生命科學系列產品包括世界上zui大的ELISA試劑盒產品線，上萬種人類的生物標志物分析的產品、酶抑制劑、單抗、多抗。產品廣泛應用于細胞凋亡、多抗藥性、氧化/ DNA損壞和修復、骨生物學、癌癥、心臟健康、炎癥、壓力與應激、肥胖和糖尿病等研究領域。

zui近，KAMIYA又推出了創新性的基于K-ASSAY化學檢測試劑的胰島素、D-二聚體(D-Dimer)，Factor XIII，纖維蛋白原降解產物(Plasma FDP)，血清/尿液FPD及FDP-E(纖維蛋白原降解產物E片段)和總IgE等因子的檢測試劑。

KAMIYA現在擁有zui全的血清蛋白免疫檢測試劑產品線，為醫院、醫療中心、臨床實驗室、臨床參考實驗室、研究所等眾多機構提供專業的臨床診斷和科研試劑產品。

品名: Anti-LSD1 pAb

貨號: PC-543 (100 µg)

Synonyms:Anti-Lysine-Specific Histone Demethylase, anti-Amine Oxidase Flavin Containing Domain Protein 2, anti-AOF2.

Format:100 µg of polyclonal antibody in PBS containing

0.02% sodium azide. Purified by immunoaffinity chromatography.

Background:

Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction. Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription. LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation. Experiments have shown that CoREST, a SANT domain-containing co-repressor acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein, inhibits CoREST/LSD1 activity in vitro. LSD1-mediated histone demethylation thus may have significant effects on gene expression.

Storage: Store at 4°C.

Applications and Suggested Dilutions: Western blot:  Use at 1 - 2 µg/mL.

Immunohistochemistry:  Use at ~ 2 µg/mL.

The optimal dilution for a specific application should be determined by the researcher.

Figure 1: Western blot analysis of LSD1 in P815 cell lysate with anti-LSD1 pAb at (A) 1 µg/mL and (B) 2 µg/mL.

Specificity:  Recognizes LSD1.

Positive Control:  P815 cell lysate.

Species Reactivity:

Human, mouse and rat. Other species not tested.

Host:  Rabbit

Immunogen:

Raised against a 16 amino acid peptide from near the center of human LSD1 (Genbank accession No. NP_001009999).

Figure 2: Immunohistochemistry of LSD1 in human small intestine tissue with LSD1 antibody at 2 µg/mL.

Limitations:For in vitro research use only. Not for use in diagnostics or in humans.

Warranty:

No warranties, expressed or implied, are made regarding the use of this product. KAMIYA BIOMEDICAL COMPANY is not liable for any damage,

personal injury, or economic loss caused by this product.

我們公司zui大優勢是強大的采購，

1：基本什么都能進口，血清，抗體，耗材，還有部分限制進口的，

2：貨品全，現經營過700多個品牌，基本所有生物試劑耗材都可以進口，特別是冷偏的產品那就更有優勢，

3：提供加急服務，一般1-2周到貨，超過時限加急費全免

4：價格公道，絕大部分價格有優勢，當然不能保證100%產品都是,因為意味著沒有服務.

5：良好的信譽，大部分客戶我們提供貨到付款服務，客戶包括清華，北大 交大 復旦，中山等100多所大學，ROCHE，阿斯利康，國藥 ，fisher等500多家公司

6：我們*代理的品牌有：Antibody Research Corporation，arcticzymes，Biorelevant，AmberGen, Inc. ，clemente-associates，clodronaiposomes，Columbia Biosciences，enzyme research，Gene Bridges GmbH，Genovis，AmberGen, Inc.  Biotechnology GmbH，Haematologic Technologies HTI Haemtech，hookelabs，Immudex，Innovative Research of America，inspiralis ，List Biological Laboratories, Inc.，lumafluor，Microsurfaces，multiplicom，nanotools，Pel-Freez Biologicals，pentapharm，progen，Protein Ark，QA-Bio,Inc，QA-Bio,IncQuickZyme Biosciences，Teknova，TriLink BioTechnologies, Inc.，Zyagen Laboratories 等

7：我們還是invitrogen,qiagen,Midland BioProducts Corporationam,sigma;neb,roche,merck, rnd,BD, GE,pierce,BioLegend等知名*批發，歡迎合作。